CyCa OncoSolutions is an early-stage, biotech company working on a unique drug delivery system. Their invention is a molecular nanomachine – CyCa-dds – that can deliver molecular payloads such as small molecules (anticancer drugs, antibiotics, fluorescent dyes) and biomolecules (genes/nucleotides/proteins) into mammalian, bacterial and plant cells. The nanomachine employs a unique mechanism to deliver molecular payloads into living cells without damaging the cells. Currently, they are exploring applications of the new drug delivery system in cancer therapy. In future, the system can be expanded across multiple industries, including :
- Lab Reagents
Cyca Oncosolutions was co-founded by Dr Nusrat Sanghamitra and Valmiki Kempadoo, and has joint operations in Cork, Ireland.
Know more: http://cycaonco.com/
Fastsense Diagnostics is focused on developing low-cost high efficiency diagnostics devices for complex diseases such as cancer. Their current focus is to develop a hand-held portable electrochemical diagnostic/screening system for liver cancer. Cancer is a complex disease and there is no portable system is available for primary screening or monitoring. The proposed device will be critical in primary screening and monitoring of liver cancer in remote areas or resource-poor regions where even basic heath care facilities are not available. FastSense Diagnostics was founded by Dr. Preeti Joshi. The team has basic expertise in nanotechnology, electrochemistry, biomedical devices and electronics.
MediAsha Technologies is a healthcare startup focusing on solving unmet needs and bringing forth novel medical devices. The company has developed its first product ‘InstaSplint’, a first-aid device that immobilizes a fractured limb until the person is taken to the hospital. The splint helps in providing rest to the injured area, preventing further displacement of bone fragments and thus protecting the underlying vessels and nerves from the fracture fragments. MediAsha is a recepient of BIRAC’s Biotechnology Ignition Grant among other awards.
MediAsha was founded in February 2018 by Mr. Mayur Sanas who is currently pursuing his PhD from the College of Engineering Pune.
Kozhnosys is a start-up involved in the development of biomedical devices with the aim of building cost-effective and easy to use medical diagnostic devices using cutting-edge technology. Currently they are developing a routine screening device for cancer. The company is working towards demonstrating proof of concept for a novel molecular-imprinted polymer coated quartz crystal microbalance sensor for rapid breath based routine screening for breast cancer, by identifying elevated concentration of volatile markers in exhaled breath.
In-Med Prognostics brings affordable, accessible, reliable, and data-driven brain health prognostics and diagnostics tools to India and other emerging markets. Their proprietary software, Neuroshield™ integrates MRI images, clinical reports and psychological assessments to produce automated, quantified reports to support the physician’s clinical impression for various neurological disorders and provides a seamless, end-to-end cloud based image analysis platform for clinical and research use. Leveraging state-of-the-art data analytics and deep learning methodologies, they are developing a biomarker algorithm for various neurological disorders starting with paediatric epilepsy and dementia.
Currently, they offer segmentation services and comparative volumetric analysis reports to clinical end-users and research support for clinical imaging based projects for pharma and life sciences customers. Their aim is to build an Indian databank for neurological disorders consisting of complete clinical data including radiology. In-Med was founded by Rajesh Purushottam, Dr. Latha Poonamallee & Dr. Al Curran.
Dzeal is developing indigenous innovations in the field of dentistry. The products and services that they are developing and intend to develop are:
(a) Rotary Endodontic file in basket form to be used in root canal treatment of teeth.
(b) GumCair: An innovative medical device that will use air/ gas to heal or to prevent the progression or recurrence of gum disease (periodontitis) after primary clinical cure
(c) Healer: A software that may be combined with hardware to help keep track of disease and prescriptions. The primary aim is to be able to register the incidence of disease pattern and the pattern of drug use geographically. The software can be particularly useful to government agencies in regulating the indiscriminate use of antibiotics and obtaining live data for monitoring the prevalence of disease in a particular area.
(d) Dental Services: DZeal also plans to providing evidence-based dental treatment at affordable rates. They are currently working from one location in Mumbai, and hope to expand their network in the near future.
Vidcare Innovations is a startup trying to re-invent how diagnostics are performed by employing microfluidic principles, to develop an equipment-free, over the counter, quantitative immunoassay testing platform technology. The company, in the long run, envisions to empower people to diagnose for various medical conditions at home, with similar easy to use, rapid diagnostic products. Currently, the company is focused on solutions for maternal and child health, with the first offering being a TSH test for screening of hypothyroidism during pregnancy.
Vidcare Innovations was founded in 2017 by Rohan Aggarwal, who holds a B.Tech in Biotechnology from Indian Institute of Technology Roorkee.
Shapecrunch is aiming to reinvent custom foot products with 3D Printing & Shapecrunch‘s Mobile app. It makes 3D models of foot orthotics from photos of feet using computer vision & machine learning. The mobile app eliminates the need for a scanner for doctors and the 3D printing technology lowers the cost, thereby saving time, money, effort and providing consistent quality. The same technology can be used for making prosthetics and even custom footwear too. The technology is being used by 25 clinics in India. Shapecrunch is seed funded, and has been accepted for a SPARSH BIRAC grant.
Vitiligo is a skin condition in which white patches appear on the skin due to the death of color-producing cells. This debilitating disease is a cause of immense psychological torment and is considered as a social stigma. At Ahammune, their endeavour is to resolve and treat the long-standing skin depigmentation disorder Vitiligo that has
affected the life of millions of people. They are currently developing new chemical/molecular entities (NCE/NME’s) for stalling the spread of depigmentation in Vitiligo.
Early wound assessment and management is very crucial with the rise in Skin and Soft Tissue Infections (SSTI), ranging from diabetic foot ulcers, surgical site infections, burns, dermatology skin infections etc. Although it was estimated that an ankle is lost to diabetes somewhere in the world every 30 seconds, a more important fact is that up to 85% of all amputations in diabetes should be preventable. Conventional methods of SSTI monitoring are very ineffective. The problem is further compounded in low resource settings due to lack of quality infrastructure. Adiuvo Diagnostics is developing a non-invasive, portable Skin-Scope device to detect, classify major clinically relevant bacteria and fungus causing the infections in real time, and also access the rate of healing within 2 minutes. This will aid the doctors with early and right treatment protocol.
Since their incorporation in October 2015, one of IBPL’s major research activity has been the fermentation of the bacterium – Haemophilus influenzae B (HIB) – for production of extracellular polysaccharide, which is a major constituent of vaccines such as meningococcal vaccine.
They have also been working on two separate projects: The first is a project offered by Dhampur Sugar Mills on membrane cell recycle continuous fermentation of dilute molasses to ethanol. This work is now nearing completion, and is expected to have an impact on minimizing the effluent of molasses fermentation, which is a priority for improving pollution control in the alcohol distillation industry.
In October 2016, they were also granted a project by SBIRI (BIRAC) for work on the Human Papilloma Virus vaccine using a recombinant yeast for production of Virus like particles (VLPs) that can be used in the manufacture of the quadrivalent vaccine against HPV. This is a dire need of the country as more than 270 million adolescent women/girls are at risk of cervical cancer against which the vaccine works.
Sarvoshadhi Biotech Pvt. Ltd. is working in the field of Biotechnology/Life Sciences. It works on developing and supplying cell culture media, feeds and other reagents to Biotechnology and Pharmaceutical Industries thereby supporting them in successful development and commercialization of human therapeutics.
Dee Dee Labs Pvt Ltd, founded in 2016, is a R&D startup company working in the healthcare domain. They are currently working on a non-invasive multigrasp myoelectric prosthetic arm for transradial amputee population in India and the Indian subcontinent. Their bionic arm technology platform is designed to restore anatomical function, lost by amputation, by using intelligent hardware and algorithms that can respond in a human-like way.
Avieum Life Sciences aims to develop novel inhibitors of Pseudomonas aeruginosa using Fragment based drug discovery approach and by using siderophores as drug delivery agents.
The company also supports global pharmaceutical R&D organizations to accelerate their drug discovery research.
With a proven expertise in synthetic and medicinal chemistry, pre-clinical drug discovery and fragment based drug discovery, the company offer services to support drug discovery from hit identification to lead optimization, custom synthesis, impurity synthesis, reference standards, route scouting and process development.
The company is founded by Dr. Ramesh Kale who did his PhD in Synthetic Organic Chemistry from CSIR-NCL and has 12 years of experience in synthetic and medicinal chemistry, drug discovery and pathogen detection.
Altreal Bioinnovation Pvt Ltd is a spin-off based on CSIR-NCL’s capabilities and created under Lab2Mkt program of Venture Center. The aim of the startup is to develop affordable prostheses for rehabilitation for the Indian healthcare mass market. They are developing explant prosthetics such as nose , ear and eye based on silicone.
The company is a recipient of “Biotechnology Ignition Grant” of DBT-BIRAC, GoI.
Genrich Membranes Pvt. Ltd., a spin-off company based on proprietary technology from CSIR-National Chemical Laboratory, Pune, uses hollow fiber membrane technology to offer cost-effective solutions for O2 enriched sterile air for medical applications (oxygen therapy) for patients suffering from respiratory diseases (asthma, COPD, neonatal, etc.). The developed membrane-based oxygen enrichment unit elevates the amount of O2 in ambient air to only 35%, thus making it a more energy efficient process compared to existing technologies. Moreover, the current OEU is adaptable to diverse applications (rural health centers, hospitals, home care, ambulance, oxygen booths/spas, etc.). In addition, since there is no fouling, these membrane systems can be expected to have a long operational life with minimum maintenance. Genrich membranes has received Biotechnology Ignition Grant by DBT-BIRAC, GoI
Orthocrafts is a spin-off based on NCL ‘s technology created under Venture Center’s “Lab2Mkt” program. The start-up focuses on the development of high molecular weight polylactic acid based bioabsorbable implants. The company will eventually cater to the sports medicine market of India. Orthocrafts has received Biotechnology Ignition Grant by DBT-BIRAC, GoI
Abhiruchi is a spin-off based on NCL ‘s technology created under Venture Center’s “Lab2Mkt” program . The company is working towards demonstrating the proof of concept for a novel formulation (patent protected) comprising a strain of Brevibacterium casei AP9 for a probiotic food additive, which will help reduce cholesterol absorption in the GI tract with potential long lasting action (as seen by higher and faster in-vitro Bile Salt Hydrolase(BSH) production than other LABs and as seen by higher adhesion to mucin layer). Abhiruchi has received Biotechnology Ignition Grant by DBT-BIRAC, GoI
Biolmed is a spin-off based on NCL ‘s technology created under Venture Center’s “Lab2Mkt” program. The start-up aim to develop biomedical products for healthcare applications for human bone defects like bony voids, long bone defects and traumatic /surgical osseous defects. The company’s first product will be a osteoconductive bone graft substitute kit based on the silk-fibroin material. Biolmed has received Biotechnology Ignition Grant by DBT-BIRAC, GoI
SynThera Biomedical focuses on R&D, manufacture and commercialization of biomaterials-based medical devices that combine innovation with affordability. Their R&D expertise lies in the development of bioactive phosphate based glasses for use as synthetic bone graft materials in dental, maxillofacial and orthopaedic applications. The company has won the “LexInnova-Venture center award for Inventive Enterpsise” an award for free IP services under CSR initiative of Venture Center.
ExoCan is the first exosomes based company in India working in the Oncodiagnostic and Therapeutics space. ExoCan is dedicated to build innovative technology platforms in the frontiers of exosomes research by using their propriety technologies. It aims to translate the clinical potential of these tiny vesicles for better management of cancers by employing cross-disciplinary approaches at the forefront of exosomes research. The company is building up a broad range of biofluids e.g. urine, saliva, blood based platforms suitable to end users and clinicians alike. This platforms offer following advantages over existing exosomes based technologies for cancer diagnosis:
1.Rapid, and sensitive method for enriching exosomes from biofluids
2. Enhanced selectivity of the test
3. High yield and precision
4. Choice based use of technology
The company has received Biotechnology Ignition Grant by DBT-BIRAC, GoI, Exocan is founded by Aman Sharma who is persuing his Ph.D from NCCS, Pune
Module is a spin-off based on NCL ‘s technology created under Venture Center’s “Lab2Mkt” program. The start-up is developing affordable and innovative diagnostic devices for rapid microbial detection. The company will leverage the platform technology developed at CSIR-NCL Pune to develope quick, colorimetric, portable and reusable biosensor based on nanofibers for E.coli O157:H7 sensing and detection. The team has already demonstrated reversible thermal chromism and solvent chromism in nanofibers of PCDA/PHBV by doping ZnO nanoparticles and Color change by Biotin-Streptavidin interaction in solution phase. The company has received Biotechnology Ignition Grant by DBT-BIRAC, GoI. They have also been featured at various news media including Economic Times, Times of India and Pixr 8. Module is founded by two engineers Sachin Dubey and usman Khan both of them holding B.Tech and M.tech from University of Rajasthan, Jaipur.
Actorius Innovations and Research Pvt Ltd (AIR) is a research and development company focused on creating novel biomaterials that have critical applications in the life science, drug delivery and medical diagnostics field. The company strives to develop in-house platform technologies that will fulfill a current need in medical procedure by improving upon an existing technology or device, or an unmet need that is clearly defined and acknowledged by medical professionals. AIR is founded by Dr. Jayant Khandare who is an NCL alumnus and Ex-Piramal Life Sciences, Dr. Muralidhara Padigaru who is also an ex-Piramal Life Sciences and Ph.D from PGIMER, Chandigarh. The third co-founder of AIR is Arvindan Vasudevan who has Master’s degree in Chemistry and a Certificate in Business Studies (Marketing).
AIR has received Biotechnology Ignition Grant and Small Business Innovation Research Initiative (SBIRI) grant by DBT-BIRAC, GoI.
Periwnkle Technologies is a platform based company for comprehensive healthcare management through mobile and web based app. Their proprietary app called “Bhramar Health” is an unique healthcare platform. Periwinkle is founded and run by Koustubh Naik and Veena Moktali. both of the founders hold BE and MS in Engineering Management from San Jose State University. The company is a recipient of SPARSH grant by DBT-BIRAC, GoI
Founded in 2010, Shantani Proteome Analytics Pvt. Ltd. is a privately-held biotechnology company that provides novel chemical-proteomics based technologies and services to identify & validate drug targets; thus de-risking molecules and supporting crucial GO / NO-GO decisions throughout the drug discovery process. The company has received SPARSH and SBIRI grant by DBT-BIRAC , GoI. The company has also raised early stage seed capital and angel funding. Shantani is founded by Dr. Chaitanya Saxena who is a seasoned professional and bring successful experience of developing technologies for drug-target deconvolution and drug-target interaction measurements in intact biological systems from his tenure at Eli Lilly & Company. Chaitanya earned a Ph.D. from The Ohio State University, Columbus, OH, USA.
Seagull Biosolutions is in to immunotherapies & affordable vaccines. The company is working towards building a technology platform for modern, effective, affordable medicines through disruptive vaccine development technology that produces affordable vaccines rapidly. Their proprietary vaccine development platform is called “eSAME” and “Active Virosomes” technologies. Seagull is founded by Dr. Vishwas Joshi who is an alumnus of IISc , Bangalore and ex-Glenmark Pharmaceuticals. The company has received Biotechnology Ignition Grant by DBT-BIRAC, GoI, Grant from Bill & Melinda Gates foundation, raised seed investment and corporate grant.
Embryyo is a medical devices and healthcare solutions based company. They are working for devoloping innovative medical devices like Pill-box for TB drug adherance monitoring, non-invasive billirubin meter for neonatal jaundice, cervical cancer screening, etc for addressing women and maternal health, child health, public health. The company is Bill & melinda gates foundation grantee and winner of Grand challenges in TB control and Global health. Embryyo has also received SPARSH grant by DBT-BIRAC, GoI. They are the winner of USAID and “Innovator for Digital India Challenge”. Embryyo is founded by Nishant kumar who is an alumnus of IIT-Bombay and Ex-Philips Healthcare
Nayam innovations is a biomaterial based company working towards developing novel Intra-Ocular Lens (IOL) to provide spectacle-free vision to patients undergoing cataract surgery. The company has received Biotechnology Ignition Grant by DBT-BIRAC, GoI, and raised seed funding through grant and equity investments. Nayam Innovations is founded by Tanuj Gigras who holds a B.Tech and M.Tech in Engineering Physics from IIT Bombay.